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Magnesium Citrate vs Magnesium L-Threonate

Compare Magnesium Citrate and Magnesium L-Threonate: timing, food, doses, forms and existing interaction guidance.

Magnesium Citrate vs Magnesium L-Threonate
Magnesium CitrateMagnesium L-Threonate
CategoryMineralsMinerals
Best timeBreakfast / DinnerBedtime
FoodWith or without foodWith or without food
Common dose100–350 mg100–150 mg
Upper limit
350 mg/day

UL applies to all supplemental magnesium combined (not food); mainly to prevent diarrhea.

350 mg/day

UL applies to all supplemental magnesium combined (not food); mainly to prevent diarrhea.

SolubilityWater-solubleWater-soluble
DescriptionOne of the better-absorbed, inexpensive forms: in a randomized comparison it raised magnesium levels more than amino-acid chelate or oxide. Its laxative effect is useful for constipation but limits the dose some people tolerate.Form designed to raise magnesium in the brain, which it did in rats. In an industry-sponsored randomized trial in adults with sleep complaints, it improved sleep-quality scores. It supplies little elemental magnesium per gram, so it's a poor way to correct a deficiency.
Timing noteAny time of day, with a glass of water. Larger doses loosen stools — it's also sold as a laxative.Commonly taken in the evening, sometimes split morning and evening.
Forms to look for
  • Capsules or powder dosed in elemental magnesium
  • Split the dose if it upsets your stomach
  • Magtein® (the studied ingredient)
  • Labels often show the threonate compound (about 2 g/day), which is under 10% magnesium
References
  1. 01NIH Office of Dietary Supplements — Magnesium Fact Sheet for Health Professionals
  2. 02Walker AF et al. Mg citrate found more bioavailable than other Mg preparations in a randomised, double-blind study. Magnes Res 2003.
  1. 01Slutsky I et al. Enhancement of learning and memory by elevating brain magnesium. Neuron 2010.
  2. 02Hausenblas HA et al. Magnesium-L-threonate improves sleep quality and daytime functioning in adults with self-reported sleep problems: a randomized controlled trial (industry-sponsored). Sleep Med X 2024.
  3. 03NIH Office of Dietary Supplements — Magnesium Fact Sheet for Health Professionals

Common product or study range — not a personal recommendation. Upper limits are ceilings, not targets.

If you take both

NoteStrong evidence

Usually unnecessary — both supply magnesium, and the amounts add up.

Pick one form, or add up the elemental magnesium on both labels.

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Common questions

What is the difference between Magnesium Citrate and Magnesium L-Threonate?

Magnesium Citrate: One of the better-absorbed, inexpensive forms: in a randomized comparison it raised magnesium levels more than amino-acid chelate or oxide. Its laxative effect is useful for constipation but limits the dose some people tolerate. Magnesium L-Threonate: Form designed to raise magnesium in the brain, which it did in rats. In an industry-sponsored randomized trial in adults with sleep complaints, it improved sleep-quality scores. It supplies little elemental magnesium per gram, so it's a poor way to correct a deficiency.

Can I take Magnesium Citrate and Magnesium L-Threonate together?

Usually unnecessary — both supply magnesium, and the amounts add up.

Last reviewed Sourced from NIH fact sheets and peer-reviewed studies.How we make this contentReport an error