Longevity

Fisetin — timing, dose & interactions

Flavonoid (strawberries, apples) that showed senolytic activity and lifespan extension in mice. Human evidence is still limited to early trials.

Timing

When to take it

Take with a fat-containing meal. Senolytic protocols often use intermittent high doses — these are experimental.

Interactions

Fisetin with other supplements

No documented supplement interactions in our dataset.

Safety

Medications & health conditions

NoteBlood thinners

Fisetin has antiplatelet activity in lab studies. Theoretical additive bleeding risk; human data are lacking.

Animal / lab only
CautionCancer treatment

Antioxidants may interfere with cancer treatment. Some chemotherapy and radiation work partly through oxidative damage; high-dose antioxidants could reduce their effect. Discuss every supplement with your oncology team.

Mechanism-based
CautionPregnant or breastfeeding

Fisetin: no safety data in pregnancy. Fisetin has not been studied for safety in pregnancy or breastfeeding. Avoid unless your clinician recommends it.

Mechanism-based

Buying guide

What to look for on the label

  • Fisetin

    • Liposomal or phytosome forms for absorption

FAQ

Common questions

When is the best time to take Fisetin?

Breakfast or Lunch. Take with a fat-containing meal. Senolytic protocols often use intermittent high doses — these are experimental.

Should Fisetin be taken with food?

Yes. It is fat-soluble, so take it with a meal that contains some fat.

Sources

References

  1. 01Yousefzadeh MJ et al. Fisetin is a senotherapeutic that extends health and lifespan. EBioMedicine 2018.