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Ginkgo + Nattokinase

Can you take Ginkgo and Nattokinase together?

CautionMechanism-based

Be cautious — both can affect clotting, and together the effect may add up.

What to do. Avoid the combination if you take a blood thinner, bruise easily or have surgery coming up. Otherwise watch for unusual bruising or bleeding.

Mechanism

Stacking two bleeding-prone supplements

Nattokinase breaks down fibrin, and ginkgo may add to the effect of blood thinners. A brain bleed has been reported with nattokinase plus aspirin.

Evidence: Mechanism-based — Plausible biological mechanism with little direct human outcome data.

  1. 01Chang YY et al. Cerebellar hemorrhage provoked by combined use of nattokinase and aspirin in a patient with cerebral microbleeds. Intern Med 2008.
  2. 02NIH NCCIH — Ginkgo

Timing

A day with Ginkgo and Nattokinase

  1. 07:00

    On waking

    no food
  2. 08:00

    Breakfast

    with meal

Taking more than these two?

Add the rest of your stack and your medications for a complete check.

Check my full stack

Buying guide

What to look for on the label

  • Ginkgo

    • Standardized leaf extract (EGb 761-type: 24% flavone glycosides, 6% terpene lactones)

  • Nattokinase

    • Labeled in fibrinolytic units — 2,000 FU (about 100 mg) is common
    • Vitamin K2–removed versions if you take warfarin

Related

Other interactions

Ginkgo + Vitamin E

Two supplements that affect bleeding

Note→

Learn more about Ginkgo and Nattokinase

Last reviewed Sourced from NIH fact sheets and peer-reviewed studies.How we make this contentReport an error