Other
Nattokinase — timing, dose & interactions
Enzyme from natto (fermented soybeans) that breaks down fibrin, the protein in blood clots. In a meta-analysis of six randomized trials it lowered blood pressure by about 3/2 mmHg, while slightly raising cholesterol and blood sugar. Because it acts on clotting, it adds bleeding risk to blood thinners.
Timing
When to take it
Often taken away from meals, once or twice daily. Dosing is by enzyme activity (fibrinolytic units, FU), not just milligrams.
Interactions
Nattokinase with other supplements
Safety
Medications & health conditions
Nattokinase adds to bleeding risk. It breaks down fibrin, and a brain bleed was reported in a patient taking it with aspirin. Don't combine with blood thinners without your prescriber.
Nattokinase adds to bleeding risk. It breaks down fibrin, and a brain bleed was reported in a patient taking it with aspirin. Don't combine with blood thinners without your prescriber.
Stop nattokinase before surgery. It affects clotting — tell your surgeon; it's commonly paused 2 weeks before.
Nattokinase may lower blood pressure slightly. In a meta-analysis it lowered blood pressure by about 3/2 mmHg — small, but it adds to your medication.
Nattokinase: no safety data in pregnancy. Nattokinase has not been studied for safety in pregnancy or breastfeeding. Avoid unless your clinician recommends it.
Buying guide
What to look for on the label
Nattokinase
- Labeled in fibrinolytic units — 2,000 FU (about 100 mg) is common
- Vitamin K2–removed versions if you take warfarin
FAQ
Common questions
When is the best time to take Nattokinase?
On waking / Bedtime. Often taken away from meals, once or twice daily. Dosing is by enzyme activity (fibrinolytic units, FU), not just milligrams.
Should Nattokinase be taken with food?
It can be taken with or without food. Often taken away from meals, once or twice daily. Dosing is by enzyme activity (fibrinolytic units, FU), not just milligrams.
Can you take Nattokinase with Ginkgo?
Be cautious — both can affect clotting, and together the effect may add up. Avoid the combination if you take a blood thinner, bruise easily or have surgery coming up. Otherwise watch for unusual bruising or bleeding.
Sources
References
- 01Weng Y et al. Nattokinase: an oral antithrombotic agent for the prevention of cardiovascular disease. Int J Mol Sci 2017.
- 02Li X et al. Nattokinase supplementation and cardiovascular risk factors: a systematic review and meta-analysis of randomized controlled trials. Rev Cardiovasc Med 2023.
- 03Chang YY et al. Cerebellar hemorrhage provoked by combined use of nattokinase and aspirin in a patient with cerebral microbleeds. Intern Med 2008.