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Medications

Supplements and Blood pressure medication

amlodipine, beta-blockers, thiazide or loop diuretics, ACE inhibitors, ARBs

Critical

Licorice RootCriticalStrong evidence

Licorice raises blood pressure and lowers potassium. Glycyrrhizin acts like the hormone aldosterone. Even small amounts have caused serious problems in people with hypertension, and potassium loss adds to that from many diuretics. Use DGL instead, or avoid.

  1. 01NIH NCCIH — Licorice Root
  2. 02Ceccuzzi G et al. Liquorice toxicity: a comprehensive narrative review. Nutrients 2023.

Caution

Electrolyte MixCautionStrong evidence

Electrolyte mixes can add a lot of sodium. Cutting salt lowers blood pressure in trials, and some mixes deliver a large share of the 2,300 mg daily sodium limit per serving. Check the label and your readings.

  1. 01He FJ et al. Effect of longer term modest salt reduction on blood pressure: Cochrane systematic review and meta-analysis of randomised trials. BMJ 2013.
  2. 02U.S. FDA — Sodium in Your Diet

Note

CoQ10NoteHuman data

CoQ10 may lower blood pressure slightly. Monitor your blood pressure when starting CoQ10 alongside BP medication.

  1. 01NIH NCCIH — Coenzyme Q10
AshwagandhaNoteMechanism-based

Ashwagandha may lower blood pressure. Possible additive effect with blood pressure medication.

  1. 01NIH Office of Dietary Supplements — Ashwagandha Fact Sheet for Health Professionals
Green Tea ExtractNoteStrong evidence

Green tea reduces nadolol levels. High doses of green tea lowered blood levels of the beta-blocker nadolol.

  1. 01NIH NCCIH — Green Tea
CaffeineNoteStrong evidence

Caffeine can raise blood pressure temporarily. The effect is smaller in regular users, but consider timing BP readings away from caffeine.

  1. 01U.S. FDA Consumer Update — Spilling the Beans: How Much Caffeine Is Too Much? (2018)
NattokinaseNoteStrong evidence

Nattokinase may lower blood pressure slightly. In a meta-analysis it lowered blood pressure by about 3/2 mmHg — small, but it adds to your medication.

  1. 01Li X et al. Nattokinase supplementation and cardiovascular risk factors: a systematic review and meta-analysis of randomized controlled trials. Rev Cardiovasc Med 2023.
Garlic ExtractNoteStrong evidence

Garlic can lower blood pressure. In people with hypertension it lowered blood pressure by about 9/6 mmHg in a meta-analysis. Monitor your readings.

  1. 01Ried K. Garlic lowers blood pressure in hypertensive individuals, regulates serum cholesterol, and stimulates immunity: an updated meta-analysis and review. J Nutr 2016.
Niacin (Nicotinic Acid)NoteStrong evidence

Niacin flushing can drop blood pressure. Flushing can come with dizziness and a fall in blood pressure; high doses can cause hypotension. Stand up slowly after a dose.

  1. 01NIH Office of Dietary Supplements — Niacin Fact Sheet for Health Professionals
Black Seed OilNoteStrong evidence

Black seed may lower blood pressure slightly. Meta-analyses report drops of about 3/3 mmHg — small, but it adds to your medication.

  1. 01Kavyani Z et al. Antihypertensive effects of Nigella sativa supplementation: an updated systematic review and meta-analysis of randomized controlled trials. Phytother Res 2023.
L-ArginineNoteStrong evidence

Arginine can lower blood pressure. In a meta-analysis it lowered blood pressure by about 5/3 mmHg. It should not be used after a heart attack.

  1. 01Dong JY et al. Effect of oral L-arginine supplementation on blood pressure: a meta-analysis of randomized, double-blind, placebo-controlled trials. Am Heart J 2011.
  2. 02Schulman SP et al. L-arginine therapy in acute myocardial infarction: the VINTAGE MI randomized clinical trial. JAMA 2006.
L-CitrullineNoteStrong evidence

Citrulline can lower blood pressure. In a meta-analysis it lowered blood pressure by about 4/3 mmHg in middle-aged and older adults. Monitor your readings.

  1. 01Luo P et al. Does L-citrulline supplementation and watermelon intake reduce blood pressure in middle-aged and older adults? A systematic review and meta-analysis. Clin Nutr ESPEN 2025.
Tongkat AliNoteHuman data

Tongkat ali can reduce propranolol absorption. In healthy volunteers it lowered propranolol levels by about 30% (peak levels by about 40%). If you take propranolol, take them apart and check with your prescriber.

  1. 01Salman SA et al. Modification of propranolol's bioavailability by Eurycoma longifolia water-based extract. J Clin Pharm Ther 2010.
Check your stack with Blood pressure medication

Common questions

Can I take Licorice Root with Blood pressure medication?

Licorice raises blood pressure and lowers potassium. Glycyrrhizin acts like the hormone aldosterone. Even small amounts have caused serious problems in people with hypertension, and potassium loss adds to that from many diuretics. Use DGL instead, or avoid.

Can I take Electrolyte Mix with Blood pressure medication?

Electrolyte mixes can add a lot of sodium. Cutting salt lowers blood pressure in trials, and some mixes deliver a large share of the 2,300 mg daily sodium limit per serving. Check the label and your readings.

Can I take CoQ10 with Blood pressure medication?

CoQ10 may lower blood pressure slightly. Monitor your blood pressure when starting CoQ10 alongside BP medication.

Can I take Ashwagandha with Blood pressure medication?

Ashwagandha may lower blood pressure. Possible additive effect with blood pressure medication.

Can I take Green Tea Extract with Blood pressure medication?

Green tea reduces nadolol levels. High doses of green tea lowered blood levels of the beta-blocker nadolol.

Can I take Caffeine with Blood pressure medication?

Caffeine can raise blood pressure temporarily. The effect is smaller in regular users, but consider timing BP readings away from caffeine.

Last reviewed Sourced from NIH fact sheets and peer-reviewed studies.How we make this contentReport an error