Amino acids
L-Arginine — timing, dose & interactions
Amino acid the body uses to make nitric oxide. In a meta-analysis, 4–24 g/day lowered blood pressure by about 5/3 mmHg. In a trial after heart attacks, more people died on arginine than on placebo, so it should not be used after a heart attack.
Timing
When to take it
Split into two or three doses; large single doses can upset the stomach.
Interactions
L-Arginine with other supplements
Safety
Medications & health conditions
Arginine may add to the blood-pressure drop from nitrates. Both raise nitric oxide. They haven't been studied together; watch for dizziness or light-headedness.
Arginine and ED pills both lower blood pressure. Arginine raises nitric oxide, and PDE5 inhibitors amplify its effect. They haven't been studied together; watch for dizziness.
Arginine can lower blood pressure. In a meta-analysis it lowered blood pressure by about 5/3 mmHg. It should not be used after a heart attack.
Buying guide
What to look for on the label
L-Arginine
- L-arginine base or HCl
- Citrulline raises blood arginine more reliably
FAQ
Common questions
When is the best time to take L-Arginine?
Breakfast / Lunch / Dinner. Split into two or three doses; large single doses can upset the stomach.
Should L-Arginine be taken with food?
It can be taken with or without food. Split into two or three doses; large single doses can upset the stomach.
Can you take L-Arginine with L-Citrulline?
Yes — combining them lowered blood pressure more than citrulline alone in trials. Fine to combine. If you take blood-pressure medication, watch for dizziness.
Sources