Lipids

CoQ10 — timing, dose & interactions

Electron carrier in the mitochondrial respiratory chain and a lipid-soluble antioxidant. Statins lower endogenous CoQ10 levels.

Also known as Coenzyme Q10, Ubiquinol, Ubiquinone

Timing

When to take it

Take with a fat-containing meal. Some people report trouble sleeping when taken late.

Interactions

CoQ10 with other supplements

Safety

Medications & health conditions

NoteBlood pressure medication

CoQ10 may lower blood pressure slightly. Monitor your blood pressure when starting CoQ10 alongside BP medication.

Human data
NoteStatins

Statins lower CoQ10 levels. Statins block the pathway that makes CoQ10. Supplementing is reasonable, but trials on statin-related muscle pain are mixed.

Strong evidence
CautionCancer treatment

Antioxidants may interfere with cancer treatment. Some chemotherapy and radiation work partly through oxidative damage; high-dose antioxidants could reduce their effect. Discuss every supplement with your oncology team.

Mechanism-based

Buying guide

What to look for on the label

  • CoQ10

    • Ubiquinol or solubilized ubiquinone in oil softgels

FAQ

Common questions

When is the best time to take CoQ10?

Breakfast or Lunch. Take with a fat-containing meal. Some people report trouble sleeping when taken late.

Should CoQ10 be taken with food?

Yes. It is fat-soluble, so take it with a meal that contains some fat.

Can you take CoQ10 with Omega-3 (Fish Oil)?

Yes — take them with the same meal. Take both with a fat-containing meal.

Sources

References

  1. 01NIH NCCIH — Coenzyme Q10
  2. 02Bhagavan HN, Chopra RK. Coenzyme Q10: absorption, tissue uptake, metabolism and pharmacokinetics. Free Radic Res 2006.