Amino acids
5-HTP — timing, dose & interactions
Direct serotonin precursor (from Griffonia seeds). Dangerous with antidepressants and other serotonergic drugs.
Also known as 5-Hydroxytryptophan, Griffonia
Timing
When to take it
Evening. Start low — nausea is common.
Interactions
5-HTP with other supplements
Safety
Medications & health conditions
5-HTP + antidepressants: serotonin syndrome. 5-HTP raises serotonin directly. With SSRIs, SNRIs, MAOIs, triptans or tramadol it can cause serotonin toxicity. Do not combine.
5-HTP: no safety data in pregnancy. 5-HTP has not been studied for safety in pregnancy or breastfeeding. Avoid unless your clinician recommends it.
Buying guide
What to look for on the label
5-HTP
- Griffonia simplicifolia extract from a tested brand
FAQ
Common questions
When is the best time to take 5-HTP?
Bedtime. Evening. Start low — nausea is common.
Should 5-HTP be taken with food?
It can be taken with or without food. Evening. Start low — nausea is common.
Can you take 5-HTP with St. John's Wort?
No — don't combine two serotonin-raising supplements. Choose one, and never combine either with antidepressants without medical advice.
Sources