Amino acids

Creatine — timing, dose & interactions

One of the best-studied supplements: increases muscle phosphocreatine for strength and power, with emerging data for cognition. Raises blood creatinine (a lab marker) with no evidence of harm to healthy kidneys.

Also known as Creatine monohydrate

Timing

When to take it

Timing barely matters — take it daily. With a meal is convenient.

Interactions

Creatine with other supplements

Safety

Medications & health conditions

CautionKidney disease

Creatine and kidney monitoring. Creatine raises blood creatinine, the main marker used to track kidney function. Avoid unless your nephrologist agrees.

Human data
NoteBlood test in the next few days

Creatine raises blood creatinine. This can look like reduced kidney function on routine labs. Tell your doctor you take it.

Strong evidence

Buying guide

What to look for on the label

  • Creatine

    • Creatine monohydrate (Creapure® or equivalent)
    • No need for loading or fancy forms

FAQ

Common questions

When is the best time to take Creatine?

Breakfast or Lunch or Dinner. Timing barely matters — take it daily. With a meal is convenient.

Should Creatine be taken with food?

It can be taken with or without food. Timing barely matters — take it daily. With a meal is convenient.

Can you take Creatine with Caffeine?

Yes — current evidence suggests normal coffee intake is fine. No change needed for normal coffee drinkers. You can take them at different times if you like.

Sources

References

  1. 01Kreider RB et al. International Society of Sports Nutrition position stand: safety and efficacy of creatine supplementation in exercise, sport, and medicine. J Int Soc Sports Nutr 2017.