Botanicals
Saffron — timing, dose & interactions
Spice from Crocus sativus. In meta-analyses of mostly small trials, largely from Iran, saffron extract reduced depressive symptoms more than placebo and about as much as SSRI antidepressants. It is generally well tolerated; mild stomach upset is the most common side effect.
Also known as: Crocus sativus, Saffron extract
Timing
When to take it
With a meal; trials usually used about 30 mg a day, sometimes split into two doses.
Interactions
Saffron with other supplements
No documented supplement interactions in our dataset.
Safety
Medications & health conditions
Tell your prescriber about saffron. Saffron is studied as a treatment for depression, including alongside SSRIs, so its effects may add up. Don't use it to replace or stop an antidepressant on your own.
Saffron supplements: no safety data in pregnancy. Saffron supplements has not been studied for safety in pregnancy or breastfeeding. Avoid unless your clinician recommends it.
Buying guide
What to look for on the label
Saffron
- Standardized saffron extract at 28–30 mg/day
FAQ
Common questions
When is the best time to take Saffron?
Breakfast / Lunch. With a meal; trials usually used about 30 mg a day, sometimes split into two doses.
Should Saffron be taken with food?
Yes. Taking it with a meal reduces stomach upset.
Sources
References
- 01Hausenblas HA et al. Saffron (Crocus sativus L.) and major depressive disorder: a meta-analysis of randomized clinical trials. J Integr Med 2013.
- 02Shafiee A et al. Effect of saffron versus selective serotonin reuptake inhibitors (SSRIs) in treatment of depression and anxiety: a meta-analysis of randomized controlled trials. Nutr Rev 2025.
- 03Hasheminasab FS et al. Adverse events of saffron (Crocus sativus L.): systematic review of current evidence. Health Sci Rep 2026.