Vitamins
Vitamin K2 — timing, dose & interactions
Activates vitamin K-dependent proteins (osteocalcin, matrix Gla protein) that bind calcium in bone and inhibit soft-tissue calcification.
Also known as Menaquinone, MK-7
Timing
When to take it
Take with a fat-containing meal, typically alongside vitamin D3.
Dose note. No UL established. Interacts strongly with warfarin.
Interactions
Vitamin K2 with other supplements
Safety
Medications & health conditions
Vitamin K directly counteracts warfarin. Warfarin works by blocking vitamin K. Starting, stopping or changing vitamin K intake can shift your INR and clotting risk. This does not apply to DOACs (apixaban, rivaroxaban), but tell your prescriber either way.
Buying guide
What to look for on the label
Vitamin K2
- MK-7 (long half-life)
- Often sold combined with D3
FAQ
Common questions
When is the best time to take Vitamin K2?
Breakfast or Lunch. Take with a fat-containing meal, typically alongside vitamin D3.
Should Vitamin K2 be taken with food?
Yes. It is fat-soluble, so take it with a meal that contains some fat.
Can you take Vitamin K2 with Vitamin D3?
Yes — they are commonly combined and complement each other. Take together with a fat-containing meal. Do not start K2 if you take warfarin without talking to your prescriber.
Can you take Vitamin K2 with Calcium?
Yes — they are complementary. No special timing needed.
Can you take Vitamin K2 with Omega-3 (Fish Oil)?
Yes — take them with the same meal. Take both with a fat-containing meal.
Can you take Vitamin K2 with Vitamin E?
Yes at moderate doses; at high vitamin E doses, K status can suffer. Keep vitamin E moderate (≤ ~400 IU / 268 mg).
Sources