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Alpha-GPC + Citicoline

Can you take Alpha-GPC and Citicoline together?

NoteMechanism-based

No need to take both — they supply choline for the same purpose, and the pair hasn't been studied.

What to do. Pick one. Given the stroke signal seen with alpha-GPC in a large cohort, citicoline is the more conservative choice.

Mechanism

Two choline sources

Both deliver choline for acetylcholine and cell membranes; citicoline also supplies cytidine. Stacking them hasn't been tested.

Evidence: Mechanism-based — Plausible biological mechanism with little direct human outcome data.

  1. 01Lee G et al. Association of L-α glycerylphosphorylcholine with subsequent stroke risk after 10 years. JAMA Netw Open 2021.
  2. 02Nakazaki E et al. Citicoline and memory function in healthy older adults: a randomized, double-blind, placebo-controlled clinical trial. J Nutr 2021.

Timing

A day with Alpha-GPC and Citicoline

  1. 07:00

    On waking

    no food

Taking more than these two?

Add the rest of your stack and your medications for a complete check.

Check my full stack

Buying guide

What to look for on the label

  • Alpha-GPC

    • Check the actual alpha-GPC per serving — some powders are only 50% alpha-GPC

  • Citicoline

    • Citicoline sodium at the trial dose (500 mg/day)

Learn more about Alpha-GPC and Citicoline

Last reviewed Sourced from NIH fact sheets and peer-reviewed studies.How we make this contentReport an error