Alpha-Lipoic Acid + Biotin

Can you take Alpha-Lipoic Acid and Biotin together?

NoteAnimal / lab only

Yes — but long-term high-dose ALA may slightly lower biotin.

What to do. No action needed at normal doses. Consider a B-complex if you take high-dose ALA long term.

Mechanism

Lipoic acid shares biotin's transporter

Lipoic acid and biotin are both taken up by the sodium-dependent multivitamin transporter (SMVT). In animals, very high lipoic acid reduced biotin-dependent enzyme activity.

Evidence: Animal / lab only — Evidence limited to animal or cell studies.

  1. 01Prasad PD et al. Cloning and functional expression of a cDNA encoding a mammalian sodium-dependent vitamin transporter mediating the uptake of pantothenate, biotin, and lipoate. J Biol Chem 1998.
  2. 02Linus Pauling Institute Micronutrient Information Center — Lipoic Acid

Timing

A day with Alpha-Lipoic Acid and Biotin

  1. 07:00

    On waking

    no food
  2. 08:00

    Breakfast

    with meal

Taking more than these two?

Add the rest of your stack and your medications for a complete check.

Check my full stack

Buying guide

What to look for on the label

  • Alpha-Lipoic Acid

    • R-lipoic acid (stabilized) or racemic ALA

  • Biotin

    • Low doses (30–300 mcg) are enough unless deficient

Related

Other interactions

Acetyl-L-Carnitine + Alpha-Lipoic Acid

The classic mitochondrial pairing

Synergy→

Learn more about Alpha-Lipoic Acid and Biotin.