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NMN + TMG (Betaine)

Can you take NMN and TMG (Betaine) together?

SynergyMechanism-based

Yes, they can be taken together — but the reason for pairing them is a theory, not a tested benefit.

What to do. Optional. If you add TMG, take it with breakfast alongside NMN. Consider it more seriously if your homocysteine is high — a blood test can tell you.

Mechanism

The methyl-donor theory behind NMN + TMG

NAD⁺ precursors release nicotinamide, which the body clears by methylation. In a small human study, a single 300 mg dose of nicotinamide lowered plasma betaine and raised homocysteine for a few hours. TMG donates methyl groups, so it is added to offset this. No trial has tested NMN with TMG.

Evidence: Mechanism-based — Plausible biological mechanism with little direct human outcome data.

  1. 01Sun WP et al. Comparison of the effects of nicotinic acid and nicotinamide degradation on plasma betaine and choline levels. Clin Nutr 2017.
  2. 02McRae MP. Betaine supplementation decreases plasma homocysteine in healthy adult participants: a meta-analysis. J Chiropr Med 2013.

Timing

A day with NMN and TMG (Betaine)

  1. 08:00

    Breakfast

    with meal

Taking more than these two?

Add the rest of your stack and your medications for a complete check.

Check my full stack

Buying guide

What to look for on the label

  • NMN

    • Third-party tested for purity (the category has quality problems)

  • TMG (Betaine)

    • Betaine anhydrous (TMG)
    • Not the same as betaine HCl, which is a stomach-acid supplement

Related

Other interactions

NMN + Resveratrol

The NAD⁺ + sirtuin hypothesis

Synergy→

NMN + Nicotinamide Riboside (NR)

Two NAD⁺ precursors are redundant

Note→

Niacin (Nicotinic Acid) + NMN

Two routes to NAD⁺

Note→

Nicotinamide Riboside (NR) + TMG (Betaine)

The methyl-donor theory behind NR + TMG

Synergy→

Learn more about NMN and TMG (Betaine)

Last reviewed Sourced from NIH fact sheets and peer-reviewed studies.How we make this contentReport an error