Longevity
TMG (Betaine) — timing, dose & interactions
Methyl donor that recycles homocysteine back into methionine by a route that does not need folate. Doses from about 1.5 g/day lower homocysteine modestly; at 4 g/day or more it can slightly raise total cholesterol. Popular alongside NMN or NR, on a theory rather than trial evidence.
Also known as: Trimethylglycine, Betaine anhydrous
Timing
When to take it
Usually taken with breakfast; larger daily amounts can be split between meals.
Interactions
TMG (Betaine) with other supplements
Safety
Medications & health conditions
High-dose TMG can nudge cholesterol up. In a meta-analysis of randomized trials, 4 g/day or more of betaine for at least 6 weeks raised total cholesterol slightly (about 13 mg/dL). If you're treating high cholesterol, stay below that dose or recheck your lipids.
TMG: no safety data in pregnancy. TMG has not been studied for safety in pregnancy or breastfeeding. Avoid unless your clinician recommends it.
Buying guide
What to look for on the label
TMG (Betaine)
- Betaine anhydrous (TMG)
- Not the same as betaine HCl, which is a stomach-acid supplement
FAQ
Common questions
When is the best time to take TMG (Betaine)?
Breakfast. Usually taken with breakfast; larger daily amounts can be split between meals.
Should TMG (Betaine) be taken with food?
Yes. Taking it with a meal reduces stomach upset.
Can you take TMG (Betaine) with NMN?
Yes, they can be taken together — but the reason for pairing them is a theory, not a tested benefit. Optional. If you add TMG, take it with breakfast alongside NMN. Consider it more seriously if your homocysteine is high — a blood test can tell you.
Can you take TMG (Betaine) with Nicotinamide Riboside (NR)?
Yes, they can be taken together — but the reason for pairing them is a theory, not a tested benefit. Optional. If you add TMG, take it with breakfast alongside NR. Consider it more seriously if your homocysteine is high — a blood test can tell you.
Sources