Longevity
Piperine — timing, dose & interactions
Alkaloid from black pepper that inhibits glucuronidation and drug-metabolizing enzymes (CYP3A4, P-glycoprotein) — raising blood levels of curcumin and of some medications.
Also known as Black pepper extract, BioPerine
Timing
When to take it
Take at the same time as the compound you want to boost (usually curcumin).
Interactions
Piperine with other supplements
Safety
Medications & health conditions
Piperine can raise drug levels. Piperine inhibits CYP3A4 and P-glycoprotein, which clear many medications including some anticoagulants. Ask your pharmacist.
Piperine may raise statin levels. Simvastatin, lovastatin and atorvastatin are cleared by CYP3A4, which piperine inhibits — higher levels mean more risk of muscle side effects.
Concentrated piperine: no safety data in pregnancy. Concentrated piperine has not been studied for safety in pregnancy or breastfeeding. Avoid unless your clinician recommends it.
Buying guide
What to look for on the label
Piperine
- Standardized 95% piperine, usually pre-combined with curcumin
FAQ
Common questions
When is the best time to take Piperine?
Lunch or Dinner. Take at the same time as the compound you want to boost (usually curcumin).
Should Piperine be taken with food?
Yes. It is fat-soluble, so take it with a meal that contains some fat.
Can you take Piperine with Curcumin?
Yes — take them at the same time; that is the whole point of the pairing. Take in the same dose, with a fat-containing meal. If you take prescription drugs, check with a pharmacist first — or choose a piperine-free enhanced curcumin (phytosome, micellar).
Can you take Piperine with Resveratrol?
Probably yes — though the evidence comes from mice. Optional. Same drug-interaction caveat as piperine with curcumin.
Sources