Medications
Supplements and Sedatives or sleep medication
benzodiazepines, zolpidem, barbiturates
Caution
Ashwagandha may add to sedation. Combining with benzodiazepines or other sedatives may increase drowsiness.
Melatonin adds to sedation. Combining with sleep medications or benzodiazepines can increase next-day drowsiness.
Don't combine valerian with sedatives. Valerian may be sleep-inducing, and NIH advises against taking it with alcohol or sedatives.
Note
L-theanine may add a mild calming effect. Usually mild, but be cautious when first combining with sleep medication.
- 01No direct human interaction studies found in PubMed (searched 2026-09-30) — theoretical, based on mechanism
Apigenin may add to sedation. Apigenin is the flavonoid behind chamomile's calming reputation, and NIH notes theoretical reasons chamomile might interact with sedatives. Start low and avoid driving until you know how the combination affects you.
Common questions
Can I take Ashwagandha with Sedatives or sleep medication?
Ashwagandha may add to sedation. Combining with benzodiazepines or other sedatives may increase drowsiness.
Can I take Melatonin with Sedatives or sleep medication?
Melatonin adds to sedation. Combining with sleep medications or benzodiazepines can increase next-day drowsiness.
Can I take Valerian with Sedatives or sleep medication?
Don't combine valerian with sedatives. Valerian may be sleep-inducing, and NIH advises against taking it with alcohol or sedatives.
Can I take L-Theanine with Sedatives or sleep medication?
L-theanine may add a mild calming effect. Usually mild, but be cautious when first combining with sleep medication.
Can I take Apigenin with Sedatives or sleep medication?
Apigenin may add to sedation. Apigenin is the flavonoid behind chamomile's calming reputation, and NIH notes theoretical reasons chamomile might interact with sedatives. Start low and avoid driving until you know how the combination affects you.