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Botanicals

Valerian — timing, dose & interactions

Root extract used for sleep. A meta-analysis found it might improve sleep quality, but most studies had significant methodological problems. It appears safe short term (300–600 mg/day for up to 6 weeks); stopping abruptly after long use may cause withdrawal symptoms.

Also known as: Valeriana officinalis

Timing

When to take it

30–120 minutes before bed.

Interactions

Valerian with other supplements

Safety

Medications & health conditions

CautionSedatives or sleep medication

Don't combine valerian with sedatives. Valerian may be sleep-inducing, and NIH advises against taking it with alcohol or sedatives.

Mechanism-based
NoteLiver disease

Rare liver injury reported with valerian. Very rare cases of liver injury have been reported, mostly with other herbs. Its long-term effect on the liver is unknown.

Human data
CautionPregnant or breastfeeding

Valerian: no safety data in pregnancy. Valerian has not been studied for safety in pregnancy or breastfeeding. Avoid unless your clinician recommends it.

Mechanism-based

Buying guide

What to look for on the label

  • Valerian

    • Valerian root extract standardized for valerenic acid

FAQ

Common questions

When is the best time to take Valerian?

Bedtime. 30–120 minutes before bed.

Should Valerian be taken with food?

It can be taken with or without food. 30–120 minutes before bed.

Can you take Valerian with Melatonin?

Usually fine, but the drowsiness may add up — start low. Try one at a time first. Don't drive or drink alcohol after taking them.

Sources

References

  1. 01NIH NCCIH — Valerian
  2. 02Bent S et al. Valerian for sleep: a systematic review and meta-analysis. Am J Med 2006.
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