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Pterostilbene + Resveratrol

Can you take Pterostilbene and Resveratrol together?

NoteMechanism-based

No need to take both — they're chemically similar, and the pair hasn't been studied.

What to do. Pick one. If you choose pterostilbene and track your cholesterol, recheck LDL after a couple of months.

Mechanism

Two closely related stilbenes

Pterostilbene is a methylated form of resveratrol and acts on many of the same targets. No study shows added benefit from combining them, and pterostilbene alone raised LDL cholesterol in a randomized trial.

Evidence: Mechanism-based — Plausible biological mechanism with little direct human outcome data.

  1. 01Riche DM et al. Pterostilbene on metabolic parameters: a randomized, double-blind, and placebo-controlled trial. Evid Based Complement Alternat Med 2014.
  2. 02Walle T et al. High absorption but very low bioavailability of oral resveratrol in humans. Drug Metab Dispos 2004.

Timing

A day with Pterostilbene and Resveratrol

  1. 08:00

    Breakfast

    with meal

Taking more than these two?

Add the rest of your stack and your medications for a complete check.

Check my full stack

Buying guide

What to look for on the label

  • Pterostilbene

    • trans-Pterostilbene
    • If you track LDL cholesterol, recheck it after starting

  • Resveratrol

    • trans-Resveratrol
    • Micronized forms

Related

Other interactions

Piperine + Resveratrol

Piperine may increase resveratrol exposure

Synergy→

NMN + Resveratrol

The NAD⁺ + sirtuin hypothesis

Synergy→

Nicotinamide Riboside (NR) + Resveratrol

The NAD⁺ + sirtuin hypothesis (NR version)

Synergy→

Learn more about Pterostilbene and Resveratrol

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