Nicotinamide Riboside (NR) + Resveratrol

Can you take Nicotinamide Riboside (NR) and Resveratrol together?

SynergyAnimal / lab only

Fine to combine; the synergy remains a hypothesis.

What to do. Take resveratrol with a fat-containing meal; NR timing is flexible.

Mechanism

The NAD⁺ + sirtuin hypothesis (NR version)

As with NMN, NR raises NAD⁺ while resveratrol is proposed to activate sirtuins. The combination hasn't been tested in human trials.

Evidence: Animal / lab only — Evidence limited to animal or cell studies.

  1. 01Martens CR et al. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults. Nat Commun 2018.
  2. 02Walle T et al. High absorption but very low bioavailability of oral resveratrol in humans. Drug Metab Dispos 2004.

Timing

A day with Nicotinamide Riboside (NR) and Resveratrol

  1. 07:00

    On waking

    no food
  2. 08:00

    Breakfast

    with meal

Taking more than these two?

Add the rest of your stack and your medications for a complete check.

Check my full stack

Buying guide

What to look for on the label

  • Nicotinamide Riboside (NR)

    • Nicotinamide riboside chloride (Niagen®)

  • Resveratrol

    • trans-Resveratrol
    • Micronized forms

Related

Other interactions

NMN + Nicotinamide Riboside (NR)

Two NAD⁺ precursors are redundant

Note→

Piperine + Resveratrol

Piperine may increase resveratrol exposure

Synergy→

NMN + Resveratrol

The NAD⁺ + sirtuin hypothesis

Synergy→

Learn more about Nicotinamide Riboside (NR) and Resveratrol.